大学卒業後は研修医期間を経て大学院へ進学、現在まで一貫して 失明につながる網膜疾患に関する研究を継続しています。
英文の研究業績(1997~2020)
Roles of the DOCK-D family proteins in a mouse model
of neuroinflammation. J Biol Chem.
2020Namekata K, Guo X, Kimura A, Azuchi Y, Kitamura Y, Harada C, Harada T.
Normal tension glaucoma-like degeneration of the visual system in aged
marmosets. Sci Rep.
2019Noro T, Namekata K, Kimura A, Azuchi Y, Hashimoto N, Moriya-Ito K, Komaki
Y, Lee CY, Okahara N, Guo X, Harada C, Kim E, Nakano T, Tsuneoka H, Inoue T, Sasaki E, Tokuno H, Harada T.
Survival of Alpha and Intrinsically Photosensitive
Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of
Normal Tension Glaucoma. Invest Ophthalmol Vis Sci.
2019Honda S, Namekata K, Kimura A, Guo X, Harada C, Murakami A, Matsuda A, Harada T.
DOCK8 is expressed in microglia, and it regulates microglial activity during
neurodegeneration in murine disease models. J Biol Chem. 2019 Namekata K, Guo X, Kimura A, Arai N, Harada C, Harada T.
Differential effects of N-acetylcysteine on retinal degeneration in two
mouse models of normal tension glaucoma. Cell Death Dis. 2019 Sano H, Namekata K, Kimura A, Shitara H, Guo X, Harada
C, Mitamura Y, Harada T.
Recent advances in genetically modified animal models
of glaucoma and their roles in drug repositioning. Br J Ophthalmol. 2019 Harada C, Kimura A, Guo X, Namekata K, Harada T.
Role of neuritin in retinal ganglion cell death in
adult mice following optic nerve injury. Sci Rep.
2018 Azuchi Y, Namekata
K, Shimada T, Guo X, Kimura A, Harada C, Saito A, Yamagata K, Harada T.
Topical Ripasudil Suppresses Retinal Ganglion Cell
Death in a Mouse Model of Normal Tension Glaucoma. Invest
Ophthalmol Vis Sci. 2018 Akaiwa K, Namekata K, Azuchi Y, Sano H, Guo X, Kimura A, Harada C, Mitamura Y, Harada T.
Edaravone Prevents Retinal Degeneration in Adult Mice
Following Optic Nerve Injury. Invest Ophthalmol Vis
Sci. 2017 Akiyama
G, Azuchi Y, Guo X, Noro T, Kimura A, Harada C, Namekata K, Harada T.
The Renin-Angiotensin System Regulates
Neurodegeneration in a Mouse Model of Optic Neuritis. Am J Pathol. 2017 Guo X, Namekata K, Kimura A, Harada C, Harada T.
ASK1 in neurodegeneration. Adv Biol Regul. 2017 Guo X, Namekata K, Kimura A, Harada C, Harada T.
Edaravone suppresses retinal ganglion cell death in a
mouse model of normal tension glaucoma. Cell Death
Dis. 2017 Akaiwa
K, Namekata K, Azuchi Y, Guo X, Kimura A, Harada C, Mitamura Y, Harada T.
Targeting Oxidative Stress for Treatment of Glaucoma
and Optic Neuritis. Oxid Med Cell Longev.
2017 Kimura A, Namekata
K, Guo X, Noro T, Harada C, Harada T.
Valproic acid and ASK1 deficiency ameliorate optic
neuritis and neurodegeneration in an animal model of multiple sclerosis. Neurosci Lett. 2017 Azuchi Y, Kimura A, Guo X, Akiyama G, Noro T, Harada
C, Nishigaki A, Namekata K, Harada T.
Caloric restriction promotes cell survival in a mouse
model of normal tension glaucoma. Sci Rep.
2016 Guo X, Kimura A,
Azuchi Y, Akiyama G, Noro T, Harada C, Namekata K, Harada T.
Neuroprotection, Growth Factors and BDNF-TrkB
Signalling in Retinal Degeneration. Int J Mol Sci.
2016 Kimura A, Namekata
K, Guo X, Harada C, Harada T.
Dock3-NMDA receptor interaction as a target for
glaucoma therapy. Histol Histopathol.
2017 Kimura A, Namekata
K, Guo X, Harada C, Harada T.
TrkB Signaling in Retinal Glia Stimulates
Neuroprotection after Optic Nerve Injury. Am J Pathol.
2015 Harada C, Azuchi Y, Noro T, Guo X, Kimura A, Namekata K, Harada T.
Spermidine Ameliorates Neurodegeneration in a Mouse
Model of Normal Tension Glaucoma. Invest Ophthalmol
Vis Sci. 2015 Noro T, Namekata K, Azuchi Y, Kimura A, Guo X, Harada C, Nakano T, Tsuneoka H, Harada T.
Spermidine promotes retinal ganglion cell survival
and optic nerve regeneration in adult mice following optic nerve injury. Cell Death Dis. 2015 Noro T, Namekata K, Kimura A,
Guo X, Azuchi Y, Harada C, Nakano T, Tsuneoka H, Harada T.
Brimonidine suppresses loss of retinal neurons and
visual function in a murine model of optic neuritis. Neurosci Lett. 2015 Guo X, Namekata K, Kimura A, Noro T, Azuchi Y, Semba
K, Harada C, Yoshida H, Mitamura Y, Harada T.
Valproic acid prevents retinal degeneration in a
murine model of normal tension glaucoma. Neurosci
Lett. 2015 Kimura A, Guo X, Noro T, Harada C, Tanaka K, Namekata K, Harada T.
Valproic acid prevents NMDA-induced retinal ganglion
cell death via stimulation of neuronal TrkB receptor signaling. Am J Pathol. 2015 Kimura A, Namekata K, Guo X, Noro T, Harada C, Harada T.
Expression of intraocular peroxisome proliferator-activated
receptor gamma in patients with proliferative diabetic retinopathy. J Diabetes
Complications. 2015 Katome T, Namekata K, Mitamura Y, Semba K, Egawa M, Naito T, Harada
C, Harada T.
Dock3 overexpression and p38 MAPK inhibition
synergistically stimulate neuroprotection and axon regeneration after optic
nerve injury. Neurosci Lett.
2014 Semba K, Namekata K, Kimura A, Harada C, Katome T, Yoshida H, Mitamura Y, Harada T.
Neurotrophic factors.
Harada
C, Harada T.
In: Neuroprotection and Neuroregeneration
for Retinal Diseases. Springer Japan
(Toru Nakazawa, Yasushi Kitaoka, Takayuki
Harada, eds.)
Namekata K, Kimura A, Harada C, Yoshida H, Matsumoto Y, Harada T.
Namekata K, Kimura A, Kawamura K, Harada C, Harada T.
Semba K, Namekata K, Kimura A, Harada C, Mitamura Y, Harada T.
Semba K, Namekata K, Guo X, Harada C, Harada T, Mitamura Y.
原田知加子、原田高幸. Clinical Neuroscience. 2013
Namekata K, Kimura A, Kawamura K, Guo X, Harada C, Tanaka K, Harada T.
Katome T, Namekata K, Guo X, Semba K,
Kittaka D, Kawamura K, Kimura A, Harada
C, Ichijo H, Mitamura Y, Harada T. Cell Death Differ. 2013
Expression of promyelocytic leukemia protein and vascular endothelial growth
factor in aqueous humor and vitreous fluid in patients with proliferative
diabetic retinopathy.
Katome
T, Namekata K, Naito T, Semba K, Guo X, Harada C, Harada T, Mitamura Y. Diabetes Res
Clin Pract. 2012
Dock3 regulates BDNF-TrkB signaling
for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
Namekata K, Watanabe H, Guo X, Kittaka D, Kawamura K, Kimura A, Harada C,
Harada T. Genes Cells. 2012
Dock3
stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly.
Namekata K, Harada C, Guo X, Kimura A,
Kittaka D, Watanabe H, Harada T.
J Neurosci. 2012
Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy.Katome T, Namekata K, Naito T, Semba K, Guo X, Harada
C, Harada T, Mitamura Y. Diabetes Res
Clin Pract. 2012
Glia-
and neuron-specific functions of TrkB signalling during retinal degeneration
and regeneration.
Harada
C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada T. Nat Commun. 2011
Spermidine
alleviates severity of murine experimental autoimmune encephalomyelitis.
Guo X, Harada C, Namekata K, Kimura A,
Mitamura Y, Yoshida H, Matsumoto Y, Harada
T. Invest Ophthalmol Vis Sci. 2011
Regulation
of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.
Guo X, Harada C, Namekata K, Matsuzawa
A, Camps M, Ji H, Swinnen D, Jorand-Lebrun C, Muzerelle M, Vitte PA, Rückle T,
Kimura A, Kohyama K, Matsumoto Y, Ichijo H, Harada T. EMBO Mol Med. 2010
Delayed
onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.
Guo X, Harada C, Namekata K, Mitamura
Y, Yoshida H, Matsumoto Y, Harada T.
PLoS One. 2010
ASK1
deficiency attenuates neural cell death in GLAST-deficient mice, a model of
normal tension glaucoma.
Harada C, Namekata K, Guo X, Yoshida H, Mitamura Y, Matsumoto Y,
Tanaka K, Ichijo H, Harada T. Cell
Death Differ. 2010
Dock3
induces axonal outgrowth by stimulating membrane recruitment of the WAVE
complex.
Namekata K, Harada
C, Taya C, Guo X, Kimura H, Parada LF, Harada T. Proc Natl Acad Sci U S A. 2010
Expression
of NG2-positive cells during optic neuritis.
Nakamura K, Guo X, Harada C, Mitamura Y, Matsumoto
Y, Harada T. Jpn J Ophthalmol. 2010
Transcription
factor, SP1, in epiretinal membranes of patients with proliferative diabetic
retinopathy.
Yoshida-Hata N, Mitamura Y, Oshitari T, Namekata K, Harada C, Harada T, Yamamoto S. Diabetes Res Clin Pract. 2010
Interleukin-1
attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient
mice.
Namekata K, Harada
C, Guo X, Kikushima K, Kimura A, Fuse N, Mitamura Y, Kohyama K, Matsumoto
Y, Tanaka K, Harada T. Neurosci
Lett. 2009 Nov 13;465(2):160-4. Epub 2009
Effect
of geranylgeranylacetone on optic neuritis in experimental autoimmune
encephalomyelitis.
Guo X, Harada C, Namekata K, Kikushima K, Mitamura Y, Yoshida H, Matsumoto
Y, Harada T. Neurosci Lett. 2009
Interleukin-1
stimulates glutamate uptake in glial cells by accelerating membrane trafficking
of Na+/K+-ATPase via actin depolymerization.
Namekata K, Harada C, Kohyama K, Matsumoto Y, Harada T. Mol Cell Biol. 2008
May;28(10):3273-80. Epub 2008
Role
of cytokines and trophic factors in the pathogenesis of diabetic retinopathy.
Mitamura Y, Harada C, Harada T. Curr Diabetes Rev. 2005
Inhibition
of glial cell activation ameliorates the severity of experimental autoimmune
encephalomyelitis.
Guo X, Nakamura K, Kohyama K, Harada C, Behanna HA, Watterson DM, Matsumoto
Y, Harada T. Neurosci Res. 2007
Neuroprotective
effect of geranylgeranylacetone against ischemia-induced retinal injury.
Harada C, Nakamura K, Guo X, Kitaichi
N, Mitamura Y, Yoshida K, Ohno S, Yoshida H, Harada T. Mol Vis. 2007
The
potential role of glutamate transporters in the pathogenesis of normal tension
glaucoma.
Harada T, Harada C, Nakamura K,
Quah HM, Okumura A, Namekata K, Saeki T, Aihara M, Yoshida H, Mitani A, Tanaka
K. J Clin Invest. 2007
Glycated
albumin induces activation of activator protein-1 in retinal glial cells.
Okumura A, Mitamura Y, Namekata K, Nakamura K, Harada C, Harada T. Jpn
J Ophthalmol. 2007
Intracellular
sortilin expression pattern regulates proNGF-induced naturally occurring cell
death during development. Nakamura K, Namekata K, Harada C, Harada T. Cell Death Differ. 2007 Aug;14(8):1552-4. Epub 2007
Molecular
regulation of visual system development: more than meets the eye.
Harada
T, Harada C, Parada LF. Genes Dev. 2007
Effect
of photoreceptor degeneration on RNA splicing and expression of AMPA receptors.
Namekata K, Okumura A, Harada C,
Nakamura K, Yoshida H, Harada T.
Mol Vis. 2006
Role
of monocyte chemotactic protein-1 and nuclear factor kappa B in the
pathogenesis of proliferative diabetic retinopathy.
Harada C, Okumura A, Namekata K,
Nakamura K, Mitamura Y, Ohguro H, Harada
T. Diabetes Res Clin Pract. 2006 Dec;74(3):249-56. Epub 2006
Expression
of olig2 in retinal progenitor cells.
Nakamura K, Harada C, Namekata K, Harada T. Neuroreport. 2006
Effect
of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse.
Nakamura K, Harada C, Okumura A,
Namekata K, Mitamura Y, Yoshida K, Ohno S, Yoshida H, Harada T. Mol Vis. 2005
Role
of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis
in vivo.
Harada C,
Nakamura K, Namekata K, Okumura A, Mitamura Y, Iizuka Y, Kashiwagi K, Yoshida
K, Ohno S, Matsuzawa A, Tanaka K, Ichijo H, Harada T. Am J Pathol. 2006
The
role of cytokines and trophic factors in epiretinal membranes: involvement of
signal transduction in glial cells. Harada C, Mitamura Y, Harada T. Prog Retin Eye Res. 2006
Effect
of p75NTR on the regulation of naturally occurring cell death and retinal
ganglion cell number in the mouse eye.
Harada C, Harada
T, Nakamura K, Sakai Y, Tanaka K, Parada LF. Dev Biol. 2006
Activator
protein-1 in epiretinal membranes of patients with proliferative diabetic
retinopathy.
Mitamura Y, Okumura A, Harada C, Namekata K, Nakamura K, Tashimo A, Ohtsuka K, Harada T. Diabetologia. 2006
Inactivation
of NF1 in CNS causes increased glial progenitor proliferation and optic glioma
formation.
Zhu Y, Harada T, Liu L, Lush ME,
Guignard F, Harada C, Burns DK, Bajenaru ML, Gutmann DH, Parada LF. Development.
2005
Phosphorylation
of extracellular signal-regulated kinase and p27(KIP1) after retinal
detachment.
Kase S, Yoshida K, Harada T, Harada
C, Namekata K, Suzuki Y, Ohgami K, Shiratori K, Nakayama KI, Ohno S. Graefes
Arch Clin Exp Ophthalmol. 2006
Disappearance
of p27(KIP1) and increase in proliferation of the lens cells after extraction
of most of the fiber cells of the lens.
Kase S, Yoshida K, Ikeda H, Harada T, Harada C, Imaki J, Ohgami K, Shiratori K, Nakayama
KI, Nakayama K, Ohno S. Curr Eye Res. 2005
Phosphorylation
of p27(KIP1) in the developing retina and retinoblastoma.
Kase S, Yoshida K, Nakayama KI, Nakayama K, Ikeda H, Harada T, Harada C,
Ohgami K, Shiratori K, Ohno S. Int J Mol Med. 2005
Role
of neurotrophin-4/5 in neural cell death during retinal development and
ischemic retinal injury in vivo.
Harada C, Harada
T, Quah HM, Namekata K, Yoshida K, Ohno S, Tanaka K, Parada LF. Invest
Ophthalmol Vis Sci. 2005
Expression
of maf-B mRNA in the epithelium around the eyelid closure of the mouse eye at
embryonic day 18.
Kase S, Imaki J, Harada T, Harada
C, Ohgami K, Shiratori K, Sakai M, Nishi S, Ohno S, Yoshida K. Anat Embryol
(Berl). 2004 Dec;209(2):153-6. Epub 2004
Involvement
of p27KIP1 in the proliferation of the developing corneal endothelium.
Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C,
Imaki J, Ohgami K, Shiratori K, Ilieva IB, Ohno S, Nishi S, Nakayama KI. Invest
Ophthalmol Vis Sci. 2004
Activation
of nuclear factor-kappa B in the conjunctiva with the epithelial scraping of
the mouse cornea and human epidemic keratoconjunctivitis.
Kase S, Aoki K, Harada T, Harada C, Ohgami K, Shiratori K, Nishi S, Ohno S,
Yoshida K. Br J Ophthalmol. 2004
Distribution
of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal
detachment.
Yoshida K, Kase S, Nakayama K, Nagahama H, Harada
T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S,
Nakayama KI. Graefes Arch Clin Exp Ophthalmol. 2004 May;242(5):437-41. Epub
2004
Involvement
of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary
body.
Yoshida K, Nakayama K, Kase S, Nagahama H, Harada
T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S,
Nishi S, Nakayama KI. Anat Embryol (Berl). 2004
Diverse
NF-kappaB expression in epiretinal membranes after human diabetic retinopathy
and proliferative vitreoretinopathy.
Harada C, Harada
T, Mitamura Y, Quah HM, Ohtsuka K, Kotake S, Ohno S, Wada K, Takeuchi S,
Tanaka K. Mol Vis. 2004
Role
of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by
ischemic retinal injury in vivo. Harada T,
Harada C, Wang YL, Osaka H, Amanai K, Tanaka K, Takizawa S, Setsuie R,
Sakurai M, Sato Y, Noda M, Wada K. Am J Pathol. 2004
Potential
role of glial cell line-derived neurotrophic factor receptors in Müller glial
cells during light-induced retinal degeneration.
Harada C, Harada T, Quah HM, Maekawa F, Yoshida K, Ohno S, Wada K, Parada
LF, Tanaka K. Neuroscience. 2003
NF-kappaB
in epiretinal membranes after human diabetic retinopathy.
Mitamura Y, Harada T, Harada C, Ohtsuka K, Kotake S, Ohno S, Tanaka K,
Takeuchi S, Wada K. Diabetologia. 2003 May;46(5):699-703. Epub 2003 May 13.
Erratum in: Diabetologia. 2003
Neurotrophin-3
is required for appropriate establishment of thalamocortical connections.
Ma L, Harada
T, Harada C, Romero M, Hebert JM, McConnell SK, Parada LF. Neuron.
2002
Microglia-Müller
glia cell interactions control neurotrophic factor production during
light-induced retinal degeneration.
Harada T,
Harada C, Kohsaka S, Wada E, Yoshida K, Ohno S, Mamada H, Tanaka K,
Parada LF, Wada K. J Neurosci. 2002
Neurotrophic
factor receptors in epiretinal membranes after human diabetic retinopathy.
Harada
T, Harada C, Mitamura Y, Akazawa C, Ohtsuka K, Ohno S, Takeuchi
S, Wada K. Diabetes Care. 2002
Proliferation
in the posterior region of the lens of c-maf-/- mice.
Yoshida K, Kim JI, Imaki J, Hiromi I, Nishi S, Matsuda H, Harada T, Harada
C, Ohno S, Sakai M. Curr Eye Res. 2001
Involvement
of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response
to wounding of corneal epithelium.
Yoshida K, Nakayama K, Nagahama H, Harada T, Harada C, Imaki J,
Matsuda A, Yamamoto K, Ito M, Ohno S, Nakayama K. Invest Ophthalmol Vis Sci.
2002
N-acetylated-alpha-linked-acidic
dipeptidase inhibitor has a neuroprotective effect on mouse retinal ganglion
cells after pressure-induced ischemia.
Harada C, Harada
T, Slusher BS, Yoshida K, Matsuda H, Wada K. Neurosci Lett. 2000
Modification
of glial-neuronal cell interactions prevents photoreceptor apoptosis during
light-induced retinal degeneration.
Harada T,
Harada C, Nakayama N, Okuyama S, Yoshida K, Kohsaka S, Matsuda H, Wada
K. Neuron. 2000
Severe
optic disc edema without hydrocephalus in neurofibromatosis 2.
Harada
T, Sawamura Y, Ohashi T, Harada C, Shinmei Y, Yoshida K, Matsuda
H. Jpn J Ophthalmol. 1998
Functions
of the two glutamate transporters GLAST and GLT-1 in the retina.
Harada T, Harada C, Watanabe M, Inoue Y, Sakagawa T, Nakayama N, Sasaki
S, Okuyama S, Watase K, Wada K, Tanaka K. Proc Natl Acad Sci U S A. 1998
Light-induced
retinal degeneration suppresses developmental progression of flip-to-flop
alternative splicing in GluR1.
Harada T,
Harada C, Sekiguchi M, Wada K. J Neurosci. 1998
A
case of bilateral optic neuropathy and recurrent transverse myelopathy
associated with perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA).
Harada
T, Ohashi T, Harada C, Yoshida K, Maguchi S, Moriwaka F, Matsuda
H. J Neuroophthalmol. 1997
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